Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1992-01-21
1993-12-14
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435119, 4352521, 4352526, 435827, 435886, C12P 1716, C12P 1718, C12R 1465, C12R 1045
Patent
active
052701875
ABSTRACT:
Described is a process for producing a new immunosuppressant, L-682,992, a C-13, C-31 demethylated ring-rearranged analog of L-679,934, under novel fermentation conditions utilizing the microorganism, Actinoplanacete Sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
REFERENCES:
patent: 4894366 (1990-01-01), Okuhara et al.
patent: 4981792 (1991-01-01), Inamine et al.
Arison Byron H.
Chen Shieh-Shung T.
Wicker Linda S.
Lilling Herbert J.
Merck & Co. , Inc.
North Robert J.
Pfeiffer Hesna J.
Thies J. Eric
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