Process for preparing 2-trifluoromethoxy-aniline

Details Process for preparing 2-trifluoromethoxy-aniline Process for preparing 2-trifluoromethoxy-aniline

1997-07-18

1998-11-24

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564417, 564442, 564443, C07C21102

Patent

active

058409831

ABSTRACT:
2-Trifluoromethoxy-aniline, which can be used as an intermediate for example for preparing pharmaceuticals and agrochemicals, is obtained in very good yields and high purity by nitrating in a first step 1,2-dichlorotrifluoromethoxy-benzene at temperatures between -20.degree. C. and +80.degree. C. and catalytically hydrogenating the resulting nitration products (exclusively 1,2-dichloro-5-nitro-4-trifluoromethoxy-benzene and 1,2-dichloro-3-nitro-4-trifluoromethoxy-benzene) in a 2nd step, it being possible to isolate the aniline intermediates corresponding to the two nitrobenzene derivatives; the nitrobenzene and aniline derivatives mentioned, being novel compounds, are also part of the subject matter of the invention.

REFERENCES:
patent: 4059627 (1977-11-01), Kritzler et al.
patent: 4387246 (1983-06-01), Disdier et al.
Sheppard,J.Org.Chem., vol 29, No. 1 (1964) ".alpha.-Fluorinated Ethers. I. Aryl Fluoroalkyl Ethers" pp. 1-11.

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