Vectors and compounds for expression of zymogen forms of human p

Details Vectors and compounds for expression of zymogen forms of human p Vectors and compounds for expression of zymogen forms of human p

1990-02-23

1993-12-14

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 696, 435 711, 435 712, 4351723, 4352401, 4353201, 436 94, 530380, 530381, 530384, 536 221, 536 231, 536 241, 536 242, 536 2431, 536 2432, 536 2433, 935 9, 935 14, 935 22, 935 66, C12P 2102

Patent

active

052701786

ABSTRACT:
A method for the recombinant production of zymogen forms of human protein C is described. These zymogen forms differ from native zymogen protein C in their increased sensitivity to activation by thrombin and thrombin/thrombomodulin. DNA compounds, vectors, and transformants useful in the method are also disclosed.

REFERENCES:
patent: 4775624 (1988-10-01), Bang et al.
Chang, (1985), Eur. J. Biochem, vol. 151, pp. 217-224.
Marsh et al., 1983, Biochemistry 22:4170.
Endres et al., 1975, Arch. Bioch. Biophy. 168:180.
Fenton, 1981, Ann. N.Y. Acad. Sci. 370:468.

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