Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-04-17
1998-11-24
Walsh, Stephen
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 435375, 536 235, C12P 2102, C12N 1519
Patent
active
058405445
ABSTRACT:
The present invention provides a polynucleotide PTEC (prostate expressed chemokine) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
REFERENCES:
patent: 5605817 (1997-02-01), Coleman et al.
Bacon et al., "Activation of Dual T Cell Signaling Pathways by the Chemokine RANTES", Science, 269:1727-1729 (1995).
Blum et al., "Three Human Homologs of a Murine Gene Encoding an Inhibitor of Stem Cell Proliferation", DNA and Cell Biology, 9(8):589-602, (1990).
Callard et al., The Cytokine Facts Book, Academic Press,San Diego, CA, pp. 226-227, 180-187 (1994).
Covell et al., "Analysis of Hydrophobicity in the .alpha. and .beta. chemokine families and its relevance to dimerization," Protein Science, 3:2064-72 (1994).
Meurer et al., J. Exp. Med., 178:1913-1921 (1993).
Schall et al., "A Human T Cell-Specific Molecule Is A Member of a New Gene Family", The Journal of Immunology, 141(3):1018-1025, (1988).
Shin et al., "Definition of a Lipopolysaccharide-Responsive Element in the 5'-Flanking Regions of MuRantes and crg-2", Molecular and Cellular Biology, 14(5):2914-2925.
Bandman Olga
Hawkins Phillip R.
Murry Lynn E.
Basham Daryl A.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Luther Barbara J.
Walsh Stephen
LandOfFree
DNA encoding rantes homolog from prostate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA encoding rantes homolog from prostate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA encoding rantes homolog from prostate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1700816