Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-05-01
1998-11-24
Elliott, George G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, C12P 2102, C12P 2106
Patent
active
058405437
ABSTRACT:
Processes for preparing polypeptides, such as G-CSF or analogues thereof, in which fermentation is carried out in the presence of at least one amino acid which is present in an amount sufficient to give improved accumulation of the polypeptide. The amino acid may be threonine and/or leucine which is present in the growth medium at a concentration of, for example, about 1.25 to 5 g/l.
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Houtaia et al., Biotechnology Letters, vol. 1, No. 11, 775-778, 1989.
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"Glossary of Genetics and Cytogenetics", Green et al., Springer-Verlag, Berlin (1976) p. 43.
Hockney Robert Craig
Kara Bhuphendra Vallabh
Elliott George G.
Imperial Chemical Industries plc
McKelvey Terry A.
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