Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-05-09
1998-11-24
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 4352523, 536 235, C12P 2102, C12N 1563, C12N 121, C07H 2104
Patent
active
058405348
ABSTRACT:
The present invention provides a human SMT3-like protein (HSMTH) and polynucleotides which identify and encode HSMTH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HSMTH and for treating or preventing disorders associated with expression of HSMTH.
REFERENCES:
Mannen, H. et al. "Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene" Biochemical and Biophysical Research Communications (May 6, 1996), vol. 222, No. 1, pp. 178-180, May 1996.
Lapenta, V. et al. "SMT3, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family" Genomics (Mar. 1, 1997), vol. 40, No. 2, pp. 362-366, Mar. 1997.
Georgiou, G. "Optimizing the production of recombinant proteins in microorganisms" AlChE Journal (Aug. 1988), vol. 34, No. 8, pp. 1233-1248, Aug. 1988.
Meeks-Wagner, D., et al., "Normal Stoichiometry of Histone Dimer Sets is Necessary for High Fidelity of Mitotic Chromosome Transmission," Cell, 44:43-52 (1986).
Meluh, P.B. (GI 881371; 881372) GenBank Sequence Database (Accession U272331996) National Center for Biotechnology Information National Library of Medicine, Bethesda, Maryland, 20894.
Lapenta, V. (GI 170371; 170372) GenBank Sequence Database (Accession 170371; 1703721997) National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Brown, M., et al. "MIF2 is Required for Mitotic Spindle Integrity during Anaphase Spindle Elongation in Saccharomyces cerevisiae," The Journal of Cell Biology, 123:387-403 (1993).
Brown, M., "Sequence similarities between the yeast chromosome segregation protein Mif2 and the mammalian centromere protein CENP-C," Gene, 160:111-116 (1995).
Hillman Jennifer L.
Shah Purvi
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Lau Kawai
Mohan-Peterson Sheela
Wax Robert A.
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