Methods comprising calcium independent cytosolic phospholipase A

Details Methods comprising calcium independent cytosolic phospholipase A Methods comprising calcium independent cytosolic phospholipase A

1996-10-23

1998-11-24

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

424 946, 435198, C12Q 144, A61K 3846

Patent

active

058405119

ABSTRACT:
The invention provides a novel calcium-independent cytosolic phospholipase A.sub.2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.

REFERENCES:
patent: 5322776 (1994-06-01), Knopf et al.
patent: 5328842 (1994-07-01), Chiou et al.
patent: 5354677 (1994-10-01), Knopf et al.
patent: 5466595 (1995-11-01), Jones et al.
Aarsman et al., J. Biol. Chem. 264:10008 (1989).
Ackermann et al., FASEB J. 7:1237(1993).
Ackermann et al., J. Biol. Chem. 269:9227 (1994).
Angle et al., Biochim. et Biophys. Acta 962:234 (1988).
Cao et al., J. Biol. Chem. 262:16927 (1987).
Ford et al., J. Clin. Invest. 88:331 (1991).
Gassama-Diagne et al., J. Biol. Chem. 264:9470 (1989).
Gross, TCM 2:115 (1992).
Gross et al., Biochemistry 32:327 (1993).
Hazen et al., J. Biol. Chem. 268:9892 (1993).
Hazen et al., J. Biol. Chem. 265:10622 (1990).
Hazen et al., J. Biol. Chem. 266:14526 (1991).
Hazen et al., Meth. in Enzymol. 197:400 (1991).
Hazen et al., J. Clin. Invest. 91:2513 (1993).
Hazen et al., J. Biol. Chem. 266:7227 (1991).
Hazen et al., Circulation Research 70:486 (1992).
Hazen et al., J. Biol. Chem. 266:5629 (1991).
Hirashima et al., J. Neurochem. 59:708 (1992).
Kanda et al., Biochem. and Biophys Res. Comm. 163:42 (1989).
Kramer et al., J. Biol. Chem. 264:5768 (1989).
Lehman et al., J. Biol. Chem. 268:20713 (1993).
Loeb and Gross, J. Biol. Chem. 261:10467 (1986).
Leslie et al., Biochim. et Biophys Acta. 963:476 (1988).
Nijssen et al., Biochim. et Biophys Acta 876:611 (1986).
Pierik et al., Biochim. et Biophys Acta 962:345 (1988).
Ramanadham et al., Biochemistry 33:7442 (1994).
Ramanadham et al., Biochemistry 32:337 (1993).
Ross et al., Archives of Biochem. and Biophys. 238:247 (1985).
Seilhamer et al., J. Biol. Chem. 264:5335 (1989).
Ueda et al., Biochem. and Biophys. Res. Comm. 195:1272 (1993).
Ulevitch et al., J. Biol. Chem. 263:3079 (1988).
Wolf and Gross, J. Biol. Chem. 260:7295 (1985).
Yost et al., Biochem. International 24:199 (1991).
Zupan et al., J. Med. Chem. 36:95 (1993).
Zupan et al., J. Biol. Chem. 267:8707 (1992).
Zupan et al., FEBS 23427 (1991).
Clark, J.D. (1991) "A novel arachidonic acid-selective cytosolic PLA.sub.2 contains a Ca.sup.2+ -dependent translocation domain with homology to PKC and GAP" Cell 65:1043-1051.
Sharp, J.D. et al. (1991) "Molecular cloning and expression of human Ca.sup.2+ -sensitive cytosolic phospholipase A.sub.2 " J. Biol. Chem. 266(23):14850-14853.
Han, J. H. et al. (1987) "Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning" Biochemistry 26:1617-1625.
Dennis, E.A. (1994) "Diversity of group types, regulation, and function of phospholipase A2" J. Biol. Chem. 269(18):13057-13060, May 1994.

Affiliated with

Also associated with

Rating

Methods comprising calcium independent cytosolic phospholipase A does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods comprising calcium independent cytosolic phospholipase A, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods comprising calcium independent cytosolic phospholipase A will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1700638