Pharmacologically effective antagonists of arginine-vasopressin

Details Pharmacologically effective antagonists of arginine-vasopressin Pharmacologically effective antagonists of arginine-vasopressin

1989-11-03

1991-12-03

Doll, John

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Oxytocin; vasopressin; related peptides

530317, 530328, 530329, 530330, C07K 716, C07K 706, A61K 3734

Patent

active

050701878

ABSTRACT:
A unique class of vasopressin analogue antagonists is provided which have the pharmacological property in-vivo to antagonize pressor (V.sub.1) and/or antidiuretic (V.sub.2) activities. The chemical modifications to the vasopressin 9 member chain sequence at the no. 1, 2, and 4 positions yield a class of potent analogue antagonists which may be employed therapeutically to treat hypertension, congestive heart failure, various edematous situations, and a variety of symptoms due to inappropriate vasopressin secretion.

REFERENCES:
patent: 4543349 (1985-09-01), Callahan et al.
patent: 4851409 (1989-07-01), Young et al.
patent: 4876243 (1989-10-01), Marshall et al.
Lowbridge et al., Journal of Medicinal Chemistry, 1978, vol. 21, No. 3, pp. 313-315.
Huffman et al., Journal of Medicinal Chemistry 1989, vol. 32, No. 4, pp. 880-883.
Lammek et al., J. Med. Chem. 1988, vol. 31, No. 3, pp. 603-606.
Lammek and Wang et al., Peptides, 1989, vol. 10, pp. 1109-1112.
J. Ridinger, Peptide Hormones, Univ. Park Press, Baltimore, J. A. Parsons (Edit), Jun. 1976, pp. 1-7.
Lammek et al., Pol. J. Chem., 64:351 (1990).
Yim & Huffman, Int. J. Pept. Prot. Res. 21:568 (1983).
Nestor et al., J. Med. Chem. 18:284 (1975).
Vavrek et al., J. Med. Chem.: 15:123 (1972).

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