3-indolyl thioacetate derivatives and NMDA receptor antagonistic

Details 3-indolyl thioacetate derivatives and NMDA receptor antagonistic 3-indolyl thioacetate derivatives and NMDA receptor antagonistic

1990-04-25

1991-09-24

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548494, C07D20918, A61K 31405

Patent

active

050514423

ABSTRACT:
The present invention is directed to a new class of 3-indolyl thioacetate derivatives which the NMDA antagonists.

REFERENCES:
Greenamyre, J. T., "Arch, Neurol.", vol. 43, pp. 1058-1063 (1986).
Olney, J. W., "Biol. Psychiatry", 26, pp. 505-525 (1989).
Robinson et al "Glutamate and Related Neurotransmitters", pp. 446-455.
Dingledine et al, TiPS, Aug. 1990 pp. 334-338.

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