Intermediates for producing semi-synthetic cephalosporins

Details Intermediates for producing semi-synthetic cephalosporins Intermediates for producing semi-synthetic cephalosporins

1974-12-18

1976-01-20

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, 424271, 2602391, C07D50118

Patent

active

039338100

ABSTRACT:
Novel 6-APA, 7-ACA and 7-ADCA derivatives are described which comprise phosphorylated derivatives of 6-APA, 7-ACA, or 7-ADCA and the corresponding acylated derivatives thereof. The novel compounds are prepared by the reaction of 6-APA, 7-ACA, 7-ADCA or a salt thereof with a phosphorus halide in the presence of an acid acceptor and subsequently acylating the thus formed phosphorylated compound, to form a phosphorylated acylated derivative which upon hydrolysis with water splits off the protective group(s) to provide the corresponding semi-synthetic penicillin or cephalosporin having useful antibacterial activity.

REFERENCES:
patent: 3809699 (1974-05-01), Ishimaru
patent: 3875152 (1975-04-01), Seelstedt

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