Process for making optically active naphtho[1,2-b]thiazepin-4(5H

Details Process for making optically active naphtho[1,2-b]thiazepin-4(5H Process for making optically active naphtho[1,2-b]thiazepin-4(5H

1990-12-10

1993-07-06

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540495, 562431, 562433, C07D21700

Patent

active

052255573

ABSTRACT:
A process for preparing optically active naphtho[1.2-b][1,4]thiazepin-4(5H)-ones comprising resolution of rac-.beta.-[(2-amino-1-naphthalenyl)thio]-.alpha.-hydroxy-4-methoxybenzene propanoic acid and converting the optically active acids so obtained into final products is described. The end product naphtho[1,2-b][1,4]thiazepin-4(5H)-ones have activity as calcium channel blockers and accordingly are useful as agents for lowering blood pressure, and as agents for treating ischemia.

REFERENCES:
patent: 4652561 (1987-03-01), Mohacsi et al.

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