Novel .DELTA..sup.4 -androstenes

Details Novel .DELTA..sup.4 -androstenes Novel .DELTA..sup.4 -androstenes

1979-06-27

1980-11-11

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26039745, 26023955C, A61K 3156

Patent

active

042332974

ABSTRACT:
Novel .DELTA..sup.4 -androstenes of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, Y is selected from the group consisting of hydrogen, fluorine and methyl, R.sub.2 is selected from the group consisting of saturated and unsaturated alkyl of 1 to 12 carbon atoms, --CF.sub.3, aryl of 6 to 12 carbon atoms and aralkyl of 7 to 12 carbon atoms and the dotted lines in the A and B rings indicate the optional presence of one or two double bonds in the 1(2) and 6(7)-positions with the proviso that when R.sub.1 is methyl, R.sub.2 is saturated or unsaturated alkyl and the B ring is saturated, Y is methyl having anti-inflammatory activity and novel intermediates.

REFERENCES:
patent: 4168306 (1979-09-01), Teutsch et al.
JACS (1961) vol. 83, pp. 4663-4664, Article by Fried et al.

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