Lymphokine SAF and method of making

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.

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424 851, C07K 1500

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active

052255352

ABSTRACT:
A lymphokine is taught which can be used to activate and stimulate CD3.sup.+, CD4.sup.+ T cells, as well as Sezary leukemic T cells. The lymphokine can be obtained from mitogen-stimulated peripheral blood mononuclear cells or urine of Sezary Syndrome patients. The lymphokine upregulates interleukin-2 receptors.

REFERENCES:
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Rimsky et al., "Purification to Homogeneity and NH.sub.2 -Terminal Amino Acid Sequence of a Novel Interleukin 1 Species Derived from a Human B Cell Lines," Jour. of Immuno., (1986), 136:3304-3310.
Wakasugi et al., "Epstein-Barr Virus-Containing B-Cell Line Produces an Interleukin 1 That It Uses as a Growth Factor," Proc. Natl. Acad. Sci. USA, (1987), 84:804-808.
Tagaya et al., "IL-2 Receptor(p55)/TAC-Inducing Factor," Jour. of Immuno., (1988), 140:2614-2620.
Armitage et al., "Regulation of Human T Cell Proliferation of IL-7," J. Immunol. (1990), 144:938-941.
Henney, "Interleukin 7: Effects on Early Events in Lymphopoiesis," Immunol. Today (1989), 10:170-173.
Namen et al., "B Cell Precursor Growth-Promoting Activity: Purification and Characterization of a Growth Factor Active on Lymphocyte Precursors," J. Exp. Med. (1988), 167:988-1002.

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