Method for early detection of intestinal ischemia

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435188, 435968, 436518, 436811, 436815, 436804, G01N 3353, C12Q 100

Patent

active

052253295

ABSTRACT:
Disclosed is a method for the screening of pathological condition in the intestinal tract of an animal or a human being, e.g., intestinal ischemia, necrotizing enterocolitis, inflammatory bowel disease and bowel graft rejection. The method assays elevated levels of lipid binding protein, more particularly intestinal fatty acid binding protein, in a biological sample obtained from the animal or human being. Serum or urine are preferred biological samples. Preferred methods employ an immunological assay such as a radioimmunoassay or an enzyme-linked immunosorbent assay for the detection of intestinal fatty acid binding proteins in the sample.

REFERENCES:
Alpers, D. H., et al., Proc. Natl. Acad. Sci. USA 81: 313-317 (1984).
Ausubel, F. M., et al., eds., Current Protocols In Molecular Biology, John Wiley, New York, 1990 Unit 11.2.2.
Bass, N. M., and Manning J. A., Biochem. Biophys. Res. Commun. 137: 929-935 (1986).
Bradford, M. M., Anal. Biochem. 72: 248-254 (1976).
Dempsey, M. E., et al., Chem. Phys. Lipids 38: 223-237 (9185).
Gordon, J. L., et al. Chem. Phys. Lipids 38: 137-158 (1985).
Grendell, J. H., .sctn.106 in Cecil's Textbook of Medicine, 18th ed., W. B. Saunders Co., Harcourt Brace Jovanovich, Philadelphia, 1988, pp. 760-765.
Lobe, T. E., et al., J. Ped. Surg. 18: 449-452 (1983).
Ockner; R. K., and Manning, A., J. Clin. Invest. 54: 326-338 (1974).
Ockner, R. K., et al., J. Biol. Chem. 257: 7872-7878 (1982).
Sacchettini, J. C., et al., J. Biol. Chem. 263: 5815-5819 (1988).
Sacchettini, J. C., et al., Molec. Cell. Biochem. 98: 81-93 (1990).
Said, B., and Schulz, J. Biol. Chem. 259: 1155-1159 (1984).
Sweetser, D. A., et al., J. Biol. Chem. 262: 16060-16071 (1987).
Varley's Practical Clinical Biochemistry, 6th ed., CRC Press, 1988, pp. 112-113.
Crisman, T. S. et al "Measurement of Rat Heart Fatty Acid Binding Protein by ELISA . . . " 1987 J. Mol. Cell Cardiol. 19: 423-431.
Catty, D. Antibodies Volume I A Practical Approach 1988 IRL Press Ltd., Oxford, England.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for early detection of intestinal ischemia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for early detection of intestinal ischemia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for early detection of intestinal ischemia will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1688989

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.