Psychotropic benzofuran derivatives

Details Psychotropic benzofuran derivatives Psychotropic benzofuran derivatives

1991-06-21

1992-07-28

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514278, 514414, 514468, 548482, 549467, 540524, 546 16, C07D40512, A61K 3155

Patent

active

051341409

ABSTRACT:
The antipsychotic, antidepressant, anxiolytic compounds of the formula: ##STR1## wherein Z is phenyl or phenyl substituted with alkyl, alkoxy, hydroxy, halogen or methylenedioxy or Z is one of the structures ##STR2## in which m is one of the integers 0, 1 or 2; R.sup.6 is hydrogen or alkyl; Y is H.sub.2 or O; or Z, taken with R.sup.1, forms one of the structures ##STR3## R.sup.1 is hydrogen or alkyl; R.sup.2 is hydrogen alkyl or phenyl; R.sup.3 is hydrogen or alkyl; R.sup.4 and R.sup.5 are independently hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, amino, mono- or dialkylamino, alkanamido of 2 to 6 carbon atoms or sulfonamido, or R.sup.4 and R.sup.5 together form methylenedioxy, ethylenedioxy, or propylenedioxy; n is one of the integers 2, 3 or 4; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3586643 (1971-06-01), Hahn et al.
patent: 3915963 (1975-10-01), Hirose et al.
patent: 4873331 (1989-10-01), Childers et al.
patent: 4882432 (1989-11-01), Abou-Gharbia et al.
patent: 4910302 (1990-03-01), Abou-Gharbia et al.
patent: 4921958 (1990-05-01), Abou-Gharbia et al.
Fozard et al., Br. J. Pharmacol 90, 273P (1987).

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