Phenacylpyridiniothiocephalosporins

Details Phenacylpyridiniothiocephalosporins Phenacylpyridiniothiocephalosporins

1990-07-09

1992-07-28

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540221, 540227, 540301, 514201, C07D50136, A61K 31545

Patent

active

051341387

ABSTRACT:
An antibacterial 3-vic-dihydroxyaroylmethylpyridiniothiomethyl cephalosporin (I) and its salts represented by the following formula: ##STR1## (wherein, R.sup.1 is amino group or acylamino; R.sup.2 is hydrogen or methoxy; R.sup.3 is hydrogen atom or substituent; R.sup.4 is vic-dihydroxyaryl; R.sup.5 is straight or branched lower alkylene; R.sup.6 is hydrogen, a carboxy-protecting group or combined with Y a negative charge; X is --O--, --S-- or sulfinyl; and Y is a counter-ion of pyridinio or combined with R.sup.6 a negative charge),
a disinfecting and treating method of bacterial infection using it, and synthetic methods thereof are provided.

REFERENCES:
patent: 4691014 (1987-09-01), Naito et al.
patent: 4880797 (1989-11-01), Nakagawa et al.

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