Human parvulin-like protein

Details Human parvulin-like protein Human parvulin-like protein

1997-02-14

2000-03-14

Lau, Kawai

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Isomerase

4352523, 4353201, 536 232, 536 235, C12N 990, C12N 121, C12N 1563, C07H 2104

Patent

active

060371641

ABSTRACT:
The present invention provides a human parvulin-like protein (HPVLP) and polynucleotides which identify and encode HPVLP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPVLP and a method for producing HPVLP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPVLP, and their use, in the prevention and treatment of diseases associated with expression of HPVLP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPVLP for the treatment of diseases associated with the expression of HPVLP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPVLP.

REFERENCES:
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Database EST-STS, Accession number H38079, Hiller et al., The Washington University-Merck EST Project, Aug. 16, 1995.
Database EST-STS, Accession number T65915, Hillier et al., The Washington University-Merck EST Project, Feb. 20, 1995.
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Rahfeld, J.-U et al., "Conformation of the existence of a third family among peptidly-prolyl cisltrans isomerases--Amino acid sequence and recombinant production of parvulin", FEBS LETTERS, 352:180-184 (1994).
Lu, K.P. et al., "A human peptidly-prolyl isomers essential for regulations of mitosis", Letters to Nature, 380:544-547 (1996).
Maleszka, R. et al., "The Drosophila melanogasterdodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1cell division gene of Saccharomyces cerevisiae", Proc. Natl. Sci., USA, 93:447-451 (1996).
Hillier, L.et al., EMBL Sequence Database, Accession No. H38079, Jul. 27, 1995.
Hillier, L. et al., EMBL Sequence Database, Accession No. AA418536, May. 14, 1997.

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