Preparation of .alpha.-hydroxy-.beta.,.beta.-dimethyl-.gamma.-bu

Details Preparation of .alpha.-hydroxy-.beta.,.beta.-dimethyl-.gamma.-bu Preparation of .alpha.-hydroxy-.beta.,.beta.-dimethyl-.gamma.-bu

1978-12-15

1980-04-29

Milestone, Norma S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2604656, C07D30758

Patent

active

042005825

ABSTRACT:
A process for the preparation of .alpha.-hydroxy-.beta.,.beta.-dimethyl-.gamma.-butyrolactone (pantolactone) by condensation of formaldehyde with isobutyraldehyde to give hydroxypivalaldehyde, conversion of the latter to its cyanohydrin, and subsequent acid hydrolysis and lactonization, wherein formaldehyde and butyraldehyde are reacted in the presence of a tertiary amine, hydrocyanic acid, at a concentration not exceeding 1% by weight in the reaction mixture, is used to form the cyanohydrin, and the hydrolysis and simultaneous lactonization are carried out with gaseous hydrogen chloride.

REFERENCES:
patent: 2399362 (1946-04-01), Lawson et al.
patent: 2702816 (1955-02-01), Klein et al.
patent: 2852530 (1958-09-01), Ford
patent: 2863878 (1958-12-01), Lynn
Ullmanns Encyklopaedie der Technischen Chemie, vol. 18 (1967), p. 205.
Houben-Weyl, Methoden der Organischen Chemie, vol. VI/2, Part 2 (1963), pp. 656-657.

Affiliated with

Also associated with

Rating

Preparation of .alpha.-hydroxy-.beta.,.beta.-dimethyl-.gamma.-bu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Preparation of .alpha.-hydroxy-.beta.,.beta.-dimethyl-.gamma.-bu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Preparation of .alpha.-hydroxy-.beta.,.beta.-dimethyl-.gamma.-bu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1683705