Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-05-11
2000-02-08
Seaman, D. Margaret
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546315, 546318, 546344, C07D21172, C07D21170, C07D21178
Patent
active
060229748
ABSTRACT:
A process for the production of 2-chloro-5-chloromethylpyridine of the formula: ##STR1## starting from 6-hydroxynicotinic acid of the formula: ##STR2## In this way 6-hydroxynicotinic acid is reacted with an acid chloride to 6-hydroxynicotinoyl chloride of the formula: ##STR3## The latter is then catalytically hydrogenated with hydrogen to 6-hydroxy-5-hydroxymethylpyridine of the formula: ##STR4## The latter is then catalytically hydrogenated with hydrogen to 2-hydroxy-5-hydroxymethylpyridine of the formula: ##STR5## which is then chlorinated to the end product according to formula I.
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J. B. Hendrickson, Organic Chemistry, 3.sup.rd Edition, p. 782, 1970.
Studer Philipp
Werbitzky Oleg
Lonza Ltd.
Seaman D. Margaret
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