Inhibitors of .beta.-amyloid toxicity

Details Inhibitors of .beta.-amyloid toxicity Inhibitors of .beta.-amyloid toxicity

1997-11-14

2000-02-08

Celsa, Bennett

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 15, 530326, 530327, A61K 3800

Patent

active

060228598

ABSTRACT:
A .beta.-amyloid inhibitor is disclosed. In one embodiment, this inhibitor comprises a recognition element that interacts specifically with .beta.-amyloid peptide and a disrupting element that alters .beta.-amyloid aggregation. In a preferable form of the present invention, the inhibitor is a peptide.

REFERENCES:
patent: 5716614 (1998-02-01), Katz et al.
Jyothi Ghanta, et al., "A Strategy for Designing Inhibitors of .beta.-Amyloid Toxicity," J. Biol. Chem. 271(47):29525029528, 1996.
Lars O. Tjernberg, et al., "Arrest of .beta.-Amyloid Fibril Formation by a Pentapeptide Ligand," J. Biol. Chem. 271 (15):8545-8548, 1996.
Dayhoff et al., Atlas of Protein Sequence and Structure (1972) vol. 5 pp. 89-99.
Hughes et al., Proc. Nat'l. Acad. Sci. USA vol. 93 pp. 2065-2070, (Mar. 1996).

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