Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1994-11-22
1996-02-27
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 4, 435 912, 435 6, C12Q 168, C12Q 125, C12P 1934
Patent
active
054948100
ABSTRACT:
The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase in a ligase chain reaction (LCR) assay for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
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Barany Francis
Hood Leroy
Kaiser, Jr. Robert J.
Nickerson Deborah
Zebala John
Cornell Research Foundation Inc.
Grimes Eric
Wax Robert A.
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