Tissue antigen and diagnostic method for human osteoporosis usin

Details Tissue antigen and diagnostic method for human osteoporosis usin Tissue antigen and diagnostic method for human osteoporosis usin

1993-03-17

1996-02-27

Adams, Donald E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 436501, 436536, 436540, G01N 3353, G01N 33536, G01N 33541

Patent

active

054948029

ABSTRACT:
An animal tissue antigen for osteoporotic patients that reacts with antibody in a serum of human osteoporotic patients, but does not react with that in normal human serum. Preferably, a specific antigen for osteoporotic patients in rat or mouse epithelium of tongue mucous membrane, epithelium of tracheal mucous membrane, upper lip epidermis or follicular epithelium containing upper lip hair shafts, or a specific antigen for osteoporotic patients contained in cultured cells of a human squamous cell tongue carcinoma cell lines such as SCC-9 and fibroblast cell lines such as MRC-5. Osteoporosis can be both specifically and easily diagnosed by bringing the above-mentioned antigen in contact with a serum of a subject and then testing for the presence of an antigen-antibody reaction.

REFERENCES:
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Ran, et al.; The Journal of Biological Chemistry, vol. 267, No. 6, pp. 3618-3625; Feb. 25, 1992.
P. H. Hissey, K. J. Thompson & L. Bawden, "Single-Step Monoclonal Antibody Affinity Purification of Human Urogastrone from Urine," Journal of Immunological Methods, 78:211-216 (1985).
A. Voller, D. E. Bidwell & A. Bartlett, "Enzyme immunoassays in diagnostic medicine", Bull. World Health Organ., 63:55-63 (1976).
B. A. Diamond, D. E. Yelton & M. D. Scharff, "Monoclonal Antibodies, A New Technology for Producing Serologic Reagents," The New England J. Medicine, 304:1344-1349 (1981).
K. Olden & K. M. Yamada, "Direct Detection of Antigens in Sodium Dodecyl Sulfate-Polyacrylamide Gels," Analytical Biochemistry, 78:483-490 (1977).

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