Monoclonal antibodies against glycated low density lipoprotein

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 794, 435188, 43524027, 436518, 436536, 436548, 436 71, 53038825, 5303911, 5303913, G01N 33535, G01N 33577, G01N 3392, C07K 1644

Patent

active

054947910

ABSTRACT:
An antibody specifically immunoreactive with glycated LDL and methods for using the antibody are provided. The antibody can be used for quantitating amounts of glycated LDL in a sample, for monitoring glycemic control in diabetic patients, for diagnosing disease, for monitoring and diagnosing atherosclerotic cardiovascular disease, and for inhibiting accumulation of LDL cholesterol by cells in tissues subject to atherosclerotic disease.

REFERENCES:
patent: 4629692 (1986-12-01), Dean
patent: 4727036 (1988-02-01), Knowles et al.
patent: 4797473 (1989-01-01), Tarsio et al.
patent: 4876188 (1989-10-01), Smith et al.
Mullarkey, et al., "Free Radical Generation by Early Glycation Products: A Mechanism for Accelerated Atherogenesis in Diabetes", Biochem. Biophys. Res. Comm., 173(3):932-939 (1990).
Gillery, et al., "Glycation of Proteins as a Source of Superoxide", Diabete & Metabolisme (Paris), 14:25-30 (1988).
Quinn, et al., "Oxidatively Modified Low Density Lipoproteins. A Potential Role in Recruitment and Retention of Monocyte/Macrophages During Atherogenesis", Proc. Natl. Acad. Sci. USA, 84:2995-2998 (1987).
Sparrow, et al., "A Macrophage Receptor That Recognizes Oxidized Low Density Lipoprotein but Not Acetylated Low Density Lipoprotein", J. Biol. Chem., 264(5):2599-2604 (1989).
Steinberg, et al., "Beyond Cholesterol: Modifications of Low-Density Lipoprotein That Increase Its Atherogenicity", New England Journal of Medicine, 3201(14):915-924 (1989).
Lecomte, et al., "Malondialdehyde Adducts to, and Fragmentation of, Apolipoprotein B From Human Plasma", Clinica Chimics Acta 218:39-46 (1993).
Clark, B. R. et al, "Enzyme-Linked Immunosorbent Assay (ELISA): Theoretical and Practical Aspects" in Immunoenzyme techniques, E. T. Maggio, ed. CRC Press, Inc. 1980, pp. 167-179.
Kortlandt, W. et al., "A simple method for the measurement of total and glycated apolipoprotein B and its relevance to apolipoprotein-B metabolism in diabetes mellitus", Clinica Chimica Acta, vol. 186, pp. 109-118, 1989.
Johnson, et al., "Fructosamine: A New Approach to the Estimation of Serum Glycosylprotein. An Index of Diabetic Control", Clinica Chimica Acta, 127:87-95 (1982).
San Gil, et al., "Improved Estimation of Fructosamine, as a Measure of Glycated Serum Protein, with the Technicon RA-1000 Analyzer", Clin. Chem., 31(12):2005-2006 (1985).
Curtis, et al., "A Novel Method for Generating Region-specific Monoclonal Antibodies to Modified Proteins", J. Clin Invest., 72:1427-1438 (1983).
Garlick, et al., "Characterization of Glycosylated Hemoglobins", J. Clin. Invest., May 1982, pp. 1062-1072.
Nakayama, et al., "Quantitative Enzyme-Linked Immunosorbent Assay (ELISA) for Non-Enzymatically Glycated Serum Protein", J. Immunol. Methods, 99:95-100 (1987).
Shapiro, et al., "Sites of Nonenzymatic Glycosylation of Human Hemoglobin A", J. Biol. Chem., 255:3120-3127 (1980).
Cohen et al., "Production and Characterization of Monoclonal Antibodies Against Human Glycoalbumin", J. Immunol. Methods, 117:121-129 (1989).
Elizabeth Shea, et al., "Immunologic Detection and Measurement of Glycated Apoliproprotein B With Site Specific Monoclonal Antibodies", Journal of Immunological Methods, vol. 162, No. 1, 4 Jun. 1993, Amsterdam, the Netherlands, pp. 85-95.
Van-Yu, Wu, et al., "Purification of Glycated Hemoglobin Free of Hemoglobin Alc and Its Use To Produce Monoclonal Antibodies Specific For Deoxyfructosyllsine Residues in Glycohemoglobin", Biochemical and Biophysical Research Communications, vol. 176, No. 1, 15 Apr. 1991, Duluth, MN, USA, pp. 207-212.
Y. Yamamoto, et al., "Radioimmunoassay of Glycated Serum Protein Using Monoclonal Antibody to Glucitollysine and Coomassie-Brilliant-Blue-Coated Polystyrene Beads", Diabetes Research, vol. 11, No. 1, May 1989, Edinburgh, GB, pp. 45-49.
L. Sorell, et al., "Monoclonal Antibodies Against Non-Enzimatically Glycated (NEG) Proteins. They use in Quantitative ELISA for NEG Serum Proteins Measurement", Biotecnologia Aplicada, vol. 9, No. 2, 1992, La Habana, Cuba, pp. 121-129.
Nakamura, et al., "Enzyme Immunoassays: Heterogeneous and Homogeneous Systems," vol. 1: Immunochemistry, pp. 27.1-27.20, ed. D. M. Weir, 4th ed., Blackwell Scientific Publications (1986).
Goldenberg, et al., "In vivo Imaging for the Detection of Human Tumors," Cancer Imaging With Radiolabeled Antibodies, pp. 273-292, Kluwer Academic Publishers (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Monoclonal antibodies against glycated low density lipoprotein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibodies against glycated low density lipoprotein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies against glycated low density lipoprotein will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1678167

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.