Pyridine di-mevalono-lactones as inhibitors of cholesterol biosy

Details Pyridine di-mevalono-lactones as inhibitors of cholesterol biosy Pyridine di-mevalono-lactones as inhibitors of cholesterol biosy

1988-12-21

1990-08-21

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546268, 546307, 546312, 546341, 546342, 546193, 546194, 546256, 546284, 546281, 514352, 514353, 514277, 514343, 514318, 514333, 514256, 5142322, 544124, 544333, 544357, 544360, 540597, C07D40514, A61K 31445

Patent

active

049506757

ABSTRACT:
Certain trans-6,6'-[[(substituted)pyridin-3,5-diyl]-dialkane- and dialkene-diyl]bis [tetrahydro-4-hydroxypyran]-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.

REFERENCES:
Merk Index. 9th Edition, p. 7853.
F. H. Hulcher, Arch. Biochem. Biophys. 30 (1971), 146, 422.
Brown et al., J. Chem. Soc. Perkin I, (1976), 1165.
M. S. Brown & J. L. Goldstein, New England Journal of Medicine (1981), 305, No. 9, 515-517.
Journal of the American Medical Association (1984), 251, No. 3, 351-374.
F. M. Singer et al., Proc. Soc. Exper. Biol. Med. (1959), 102, 370.

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