Syn isomers of 7-[2-(2-amino-4-thiazolyl)-2-(carboxymethyloxyimi

Details Syn isomers of 7-[2-(2-amino-4-thiazolyl)-2-(carboxymethyloxyimi Syn isomers of 7-[2-(2-amino-4-thiazolyl)-2-(carboxymethyloxyimi

1979-04-03

1981-09-01

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 27, 544 28, A61K 31545, C07D50156

Patent

active

042871930

ABSTRACT:
Novel syn isomers of 7-[2-(2-amino-4-thiazolyl)-2-(carboxymethyloxyimino)-acetamido]-ceph-3-eme -4-carboxylic acid compounds of the formula ##STR1## wherein R is selected from the group consisting of alkyl of 1 to 3 carbon atoms and --CH.sub.2 --S--R.sub.1, R.sub.1 is an optionally substituted heterocyclic of 5 to 6 chain components with 1 to 4 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, magnesium, --NH.sub.4, an easily cleavable ester and a non-toxic, pharmaceutically acceptable organic amine, A.sub.1 is selected from the group consisting of alkyl of 1 to 3 carbon atoms, hydrogen, alkali metal, alkaline earth metal, magnesium, --NH.sub.4, an easily cleavable ester and a non-toxic, pharmaceutically acceptable organic amine and non-toxic, pharmaceutically acceptable acid addition salts thereof having antibiotic activity and their preparation and intermediates therefor.

REFERENCES:
patent: 4066762 (1978-01-01), Dunn
patent: 4091209 (1978-05-01), Cook et al.
patent: 4098888 (1978-07-01), Ochiai et al.
patent: 4144393 (1979-03-01), Bradshaw et al.
patent: 4166115 (1979-08-01), Takaya et al.

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