1,3-dioxan-4-ylalkenoic acids

Details 1,3-dioxan-4-ylalkenoic acids 1,3-dioxan-4-ylalkenoic acids

1984-11-09

1987-11-03

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549375, 549334, 549333, A61K 31335, C07D31906

Patent

active

047043997

ABSTRACT:
This invention concerns novel 1,3-dioxan-4-yl-alkenoic and alkanoic acids of formula I wherein Ra is (1-6C)alkyl, halogeno-(1-6C)alkyl, Rb is hydrogen or as Ra, or Ra and Rb together form (2-5C)polymethylene or (2-4C)oxypolymethylene, n is 2, 3 or 4, A is vinylene or ethylene, benzene ring B optionally bears a single substituent and the substituents at positions 4 and 5 of the dioxane ring have trans-relative stereochemistry; together with pharmaceutically acceptable salts, (1-6C)-alkyl esters and (1-6C)alkanesulphonamides thereof. The compounds of formula I are antagonists of thromboxane A.sub.2 and are of value in treating a variety of disease conditions. The invention also provides processes for the manufacture of, and pharmaceutical compostions of, the compounds of formula I.

REFERENCES:
patent: 2992234 (1961-07-01), Acker
patent: 4567197 (1986-01-01), Brewster et al.

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