Process for producing 1-substituted tetrahydroquinazolines

Details Process for producing 1-substituted tetrahydroquinazolines Process for producing 1-substituted tetrahydroquinazolines

1998-05-12

1999-11-30

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544284, C07D23972, C07D40100, C07D41300, C07D41900

Patent

active

059945427

ABSTRACT:
A process for producing 1-substituted tetrahydroquinazolines represented by the formula (III): ##STR1## wherein Z represents a methylene group which is optionally substituted by an alkyl group; R.sub.6 represents an alkyl group or an aralkyl group; R.sub.1 and R.sub.2 independently represent a hydrogen atom, a halogen atom, a nitro group, an azido group, an alkyl group, an alkenyl group, an aralkyl group, an alkoxy group, an alkoxycarbonyl group, an acyloxygroup, or an amino group represented by XNR.sub.4 R.sub.5 in which X represents a direct bond, an alkylene group or a carbonyl group, and N, R.sub.4 and R.sub.5 may form together a five- or six-membered heterocyclic ring or R.sub.4 and R.sub.5 independently represent an alkyl group or an acyloxy alkyl group; and R.sub.3 represents a hydrogen atom, a halogen atom, a nitro group, an azido group, an alkyl group, an alkenyl group, an aralkyl group,an alkoxy group, or an alkoxycarbonyl group which comprises reacting tetrahydroquinazolines represented by the formula (I): ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined above with hexamethyldisilazane; and reacting the resultant product with a chloroalkanoate represented by the formula (II):

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