Tetrahydroimidazo[2,1-A]isoquinoline derivatives

Details Tetrahydroimidazo[2,1-A]isoquinoline derivatives Tetrahydroimidazo[2,1-A]isoquinoline derivatives

1998-06-25

1999-11-30

Huang, Evelyn Mei

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514267, 544252, 546 84, 546 81, A61K 3147, A61K 31505, C07D47104

Patent

active

059943661

ABSTRACT:
The present invention relates to certain tetrahydroimidazo[2,1-a]isoquinoline derivatives according to formula I wherein X is a group (A) or (B) ##STR1## R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent one or more substituents selected from hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.4-6 cycloalkenyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl and halogen;

REFERENCES:
patent: 3624093 (1971-11-01), Sulkowski
patent: 4100165 (1978-07-01), Houlihan
Matechka D et al. J. Med. Chem. 39, 4704-4716, Nov. 1996.
M. Chaykovskyet et al., Journal of Organic Chemistry, 35:4:1178-1180, 1970.

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