Peptidyl compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514616, 564153, 564154, 435212, 4241841, 730868, A61K 3800

Patent

active

059943122

ABSTRACT:
Compounds of general formula (I): ##STR1## have utility as inhibitors of matrix metalloproteinases and TNF.

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Fournie-Zaluski et al., Eur. J. Biochem. vol. 139, 267, 1984.
Dayhoff et al., Atlas of Protein Sequence and Structure, vol. 5, Dayhoff (ed.), 1975.
Fournie-Zaluski, M. et al. (1984) "Differences in the structural requirements for selective interaction with neutral metalloendopeptidase (enkephalinase) or angiotensin-converting enzyme". Eur. J. Biochem. 139: 267-274.
Blumberg, S., Tauber, Z. (1983) "Inhibition of metalloendopeptidases by 2-mercaptoacetyl-dipeptides". Eur. J. Biochem. 136: 151-154.
Dayhoff, M.O. et al. (1992) Atlas of Protein Sequence and Structure, vol. 5. National Biomedical Research Foundation.

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