Nitrosated and nitrosylated .alpha.-adrenergic receptor antagoni

Details Nitrosated and nitrosylated .alpha.-adrenergic receptor antagoni Nitrosated and nitrosylated .alpha.-adrenergic receptor antagoni

1996-09-18

1999-11-30

Celsa, Bennett

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514242, 514248, 514280, 514307, 514400, 514471, 514509, 514523, 514532, 514396, 514649, 514684, 514929, 536 261, 4248511, 4241301, 530300, A61K 3800, C07K 506, C07K 508

Patent

active

059942940

ABSTRACT:
Disclosed are nitrosated and nitrosylated .alpha.-adrenergic receptor antagonists, compositions of an .alpha.-adrenergic receptor antagonist (.alpha.-antagonist), which can optionally be substituted with at least one NO or NO.sub.2 moiety, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO.sup.+) or nitroxyl (NO.sup.-), or as the neutral species, nitric oxide (NO.cndot.); and uses for each of them in treating human impotence or erectile dysfunction.

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