Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-11-17
1989-03-07
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548518, C07D20700, A61K 3140
Patent
active
048107212
ABSTRACT:
A novel pyrrolidineamide derivative that exhibits inhibitory activity toward prolyl endopeptidase and its use as an inhibitor against said enzyme are provided. The pyrrolidineamide of the invention has the following general formula: ##STR1## wherein R.sup.1 is benzyloxycarbonyl or a group of the formula: ##STR2## (wherein m is an integer of from 1 to 5) and R.sup.2 is hydroxy, acyloxyy or a group of the formula: ##STR3## (wherein R.sup.3 and R.sup.4 independently are a hydrogen atom, a halogen atom, a lower alkyl or a lower alkoxy).
REFERENCES:
patent: 4483991 (1984-11-01), Freed
patent: 4701465 (1987-10-01), Tanaka et al.
patent: 4757083 (1988-07-01), Higuchi et al.
The Agriculture Chemical Society of Japan, pp. 752-754 (1959).
Journal of Neurochemistry, vol. 41 (1), 69-75 (1983).
Agric. Biol. Chem., 42(12), 2417-2419 (1978).
Fukami Harukazu
Hashimoto Masaki
Higuchi Naoki
Saitoh Masayuki
Tanaka Takaharu
Lee Mary C.
Suntory Limited
Whittenbaugh Robert C.
LandOfFree
Pyrrolidineamide derivative having anti-prolyl endopeptidase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrrolidineamide derivative having anti-prolyl endopeptidase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolidineamide derivative having anti-prolyl endopeptidase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1669096