Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1986-01-31
1989-03-28
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530324, C07K 710, C07K 1300
Patent
active
048165646
ABSTRACT:
The entire hepatitis B Virus pre-S antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
REFERENCES:
patent: 4639371 (1987-01-01), Prince et al.
patent: 4683293 (1987-07-01), Craig
Ellis Ronald W.
Hagopian Arpi
Kniskern Peter J.
Levitt Julian S.
Merck & Co. , Inc.
Perrella Donald J.
Pfeiffer Hesna J.
Phillips Delbert R.
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