Opioid agonist compounds

Details Opioid agonist compounds Opioid agonist compounds

1993-02-24

1994-10-11

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49112, A61K 3144

Patent

active

053548639

ABSTRACT:
The present invention provides novel substituted opioid analgesic compounds of Formula I: ##STR1## which are opioid agonists, and which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

REFERENCES:
patent: 4816586 (1989-03-01), Portoghese
Portoghese et al, CA 112(25): 235659s (1990).
Portoghese et al. CA 111: 115661u (1989).
Olmsted et al, CA 118: 94168r (1993).
Portoghese et al, CA 117: 212759p (1992).
Dorn et al. CA 117: 48987p (1992).
Nagase et al. CA 115: 174658d (1991).
Portoghese, et al., "Design of Peptidomimetic Delta Opiod Receptor Antagonists Using the Message Address Concept," J. Med. Chem. 33, pp. 1714-1720, Jan., 1990, U.S.A.
Portoghese, et al. "Application of the Message Address Concept in the Design of Highly Potent and Selective Non-Peptide S Opiod Receptor Antagonists," J. Med. Chem. 31, No. 2, pp. 281-282, Jan., 1988, U.S.A.

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