Piptides having ANF activity

Details Piptides having ANF activity Piptides having ANF activity

1987-05-19

1989-03-28

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530326, A61K 3702, C07K 708, C07K 710

Patent

active

048164437

ABSTRACT:
Novel peptides having potent natriuretic activity are disclosed with the following amino acid sequence: ##STR1## wherein Z is H, acetyl, Boc or Ser-Leu, E is Phe, NMP, OMT, ChA, F is Gly or DAl, G is Ala or Gly, H is Arg or DAr, Pro, Lys or Dly, I is Ile, Met, MeO, MO.sub.2, Leu, Nle, or Val, J is Aib, .alpha.MG or .alpha.MA, K is Arg or Lys, L is Ile or Val, M is Aib, Gly, Ala or DAl, N is Ala, NMA, Pro, Phe or NMP, O is Gln, DGl, Ala or DAl, P is Ser, His, Arg or Lys, Q is Gly, Pro, Ala or Dal, R is Leu, Phe or ChA, S is Gly, Ala or Dal, Arg or DAr, T is Asn DAs, Ala or Dal, U is Ser, DSe, Ala or DAl, V is Phe, DPh, Ala or DAl, Y is -OH or -NH.sub.2 and n is 0 or 1. Also included are the lower alkyl esters and the physiologically acceptable metal salts and acid addition salts of the foregoing peptides. Unless indicated otherwise all optically active amino acids have the L-configuration.

REFERENCES:
patent: 4557864 (1985-12-01), Needleman
patent: 4607023 (1986-08-01), Thibault et al.
patent: 4609725 (1986-09-01), Brady et al.
patent: 4618600 (1986-10-01), Johnson et al.
patent: 4673732 (1987-06-01), Kiso et al.
patent: 4716147 (1987-12-01), Tjoeng et al.
patent: 4721704 (1988-01-01), Chang et al.

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