Murine hybridoma and diagnostic antibody produced thereby

Chemistry: molecular biology and microbiology – Spore forming or isolating process

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 68, 4351722, 435 7, 530387, 530808, 530809, 935104, 935110, 436548, 436813, G01N 33577, C12N 1500

Patent

active

048164020

ABSTRACT:
Hybridoma HB 8986 produces a murine monoclonal antibody which recognizes a new determinant expressed in bronchopulmonary carcinomas and A549 cell line derived tumors. Immunoperoxidase staining with the hybridoma on formalin fixed, paraffin embedded tissues shows that it specifically stains both the cytoplasmic and cell surface. The monoclonal antibody has the ability to distinguish preferably bronchopulmonary carcinomas with glandular differentiation from other bronchopulmonary carcinomas. Additionally, the monoclonal antibody may identify adenocarcinomas through the body.

REFERENCES:
Yarki et al., Cancer Res., 44(1984) 681-687.
Mulshine et al., J. Immunol., 131(1983) 497-502.
Yoshida et al., Chem. Abstracts 103(1985)#213228n.
Rosen et al., Cancer Res. 44(1984)2052-2061.
Mazauric et al., Cancer Res. 42(1982) 150-154.
Ho et al., Cancer, Res. 47(1987) 241-250.
Nakamura; Chem. Abstracts, 104(1986)#49618n.
S. G. Combs, et al., Expression of the Antigenic Determinant Recognized by the Monoclonal antibody 44-3A6 on Select Human Adenocarcinomas and Normal Human tissues, Manuscript (submitted for publishing).
Inchul Lee, et al., Cancer Research vol. 45, Nov. '85.
Barbara F. Banner, M.D., et al., Diag. Cytopathol, vol. 1, #4 '85.
J. A. Radosevich, et al., Cancer Research, vol. 45, Nov. '85.
Inchul Lee, et al., Amer. J. of Pathology, vol. 123, No. 3, 1986.
A. M. Zimmer, et al., Abstract for Fourth Annual Congress for Hybridoma Research, Feb. 1985.
I. Lee, et al., Abstract for American Federation for Clinical Research, Jan. 6, 1985.
I. Lee, et al., Abstract for International Academy of Pathology.
I. Lee, et al., Abstract for International Academy of Pathology.
S. G. Combs, et al., Abstract for International Academy of Pathology.
B. F. Banner, et al., Abstract for International Academy of Pathology.
B. F. Banner, et al., Abstract for 33rd Annual Meeting of the American Society of Cytology.
S. G. Combs, et al., Abstract for Midwest Section, American Federation of Clinical Research.
J. A. Radosevich, et al., Abstract for IV World Conference on Lung Cancer, Aug. 25-30, 1985, Toronto, Canada.
I. Lee, et al., Abstract for IV World Conference on Lung Cancer, Aug. 25-30, 1985, Toronto, Canada.
A. M. Zimmer, et al., Central Chapter, Society of Nuclear Medicine, Inc.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Murine hybridoma and diagnostic antibody produced thereby does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Murine hybridoma and diagnostic antibody produced thereby, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Murine hybridoma and diagnostic antibody produced thereby will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1658978

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.