Acetylenes disubstituted with a heteroaromatic group and a tetra

Details Acetylenes disubstituted with a heteroaromatic group and a tetra Acetylenes disubstituted with a heteroaromatic group and a tetra

1993-06-29

1994-10-11

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514471, 549483, 549484, 549486, 549487, 549497, A61K 3134, C07D30742, C07D30746

Patent

active

053547764

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, --COOH or an ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative thereof, or --CHO or an acetal derivative thereof, or --COR.sub.1 or a ketal derivative thereof where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4269848 (1981-05-01), Bayssat et al.
patent: 5248221 (1993-09-01), Gerhart et al.

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