Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-03-21
1996-07-30
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546176, 5483097, 548491, 564 80, 564 84, 564 92, 514399, 514412, 514601, 514602, 514604, C07D21504, A61K 3147
Patent
active
055411975
ABSTRACT:
Substituted sulfonamides are selective .beta..sub.3 adrenergic receptor agonists with very little .beta..sub.1 and .beta..sub.2 adrenergic receptor activity and as such the compounds are capable of increasing lipolysis and energy expenditure in cells. The compounds thus have potent activity in the treatment of Type II diabetes and obesity. The compounds can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compounds can be used to reduced neurogenic inflammation or as antidepressant agents. The compounds are prepared by coupling an aminoalkylphenyl-sulfonamide with an appropriately substituted epoxide. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility are also disclosed.
REFERENCES:
patent: 3452037 (1969-06-01), Santilli et al.
patent: 3816516 (1974-06-01), Cox et al.
patent: 4000193 (1976-12-01), Lunts et al.
patent: 4396627 (1983-08-01), Ainsworth et al.
patent: 4478849 (1984-10-01), Ainsworth et al.
patent: 4999377 (1991-03-01), Caulkett et al.
patent: 5017619 (1991-05-01), Alig et al.
patent: 5153210 (1992-10-01), Ainsworth et al.
patent: 5321036 (1994-06-01), Sher
A. A. Larsen, et al, Journal of Medicinal Chemistry, vol. 10, 3 pp. 462-472, Nov. 1966.
Fisher Michael H.
Naylor Elizabeth M.
Weber Ann E.
Davis Zinna Northington
Merck & Co. , Inc.
Rose David L.
Yang Mollie M.
LandOfFree
Substituted sulfonamides as selective .beta..sub.3 agonists for does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted sulfonamides as selective .beta..sub.3 agonists for , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted sulfonamides as selective .beta..sub.3 agonists for will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1658830