Soluble and its use in B cell stimulation

Details Soluble and its use in B cell stimulation Soluble and its use in B cell stimulation

1992-09-04

1996-07-30

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241731, 4241921, 435 691, 435 693, 435 697, 4352523, 4353201, 514 12, 530350, 5303871, A61K 39395, A61K 3817

Patent

active

055409261

ABSTRACT:
The present invention relates to soluble ligands for the B-cell antigen, CD40, and, in particular, to human gp39 protein and soluble ligands derived therefrom which may be used in methods of promoting B-cell proliferation.

REFERENCES:
R. J. Armitage et al. Nature 357:80-82 May 7, 1992.
Lauzan, G. J. et al. Molec. Immunol. 25(9):829-41 1988.
Lederman et al., "Identification of a Novel Surface Protein on Activated CD4+T Cells That Induces Contact-Dependent B Cell Differentiation (Help)", J Exp Med 175:1091-1101 (1992).
Noelle and Snow, "T Helper Cells", Current Opinion in Immunology 4:333-337 (1992).
Noelle et al., "A 39-kDa Protein on Activated Helper T Cells Binds CD40 and Transduces the Signal for Cognate Activation of B Cells", Proc. Natl. Acad. Sci. USA 89:6550-6554 (1992).

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