Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl)

Details Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl) Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl)

1980-09-22

1982-03-23

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20728

Patent

active

043212018

ABSTRACT:
Optically active tert-alkyl 7-2(oxo-5-carbonyloxypyrrolidinyl)heptanoates and their preparation by reaction of racemic tert-alkyl 7-(2-oxo-5-carboxypyrrolidinyl)heptanoate with an optically active amine to form resolved d or l amine salts which are then reacted with acid to form resolved acid intermediates. Esterification of these acid intermediates produces resolved d or l esters which are useful to make optically active 8-azaprostanoids having biological activity.

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