Ribosome-inactivating glycoproteins, modified by oxidation of th

Details Ribosome-inactivating glycoproteins, modified by oxidation of th Ribosome-inactivating glycoproteins, modified by oxidation of th

1986-12-15

1990-03-27

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 858, 424 92, 514 8, 530370, 530371, 530372, 530377, 530395, 530396, 530410, A61K 3944, A61K 4505, C07K 1514

Patent

active

049119125

ABSTRACT:
Glycoprotein (GPIR) having the ribosome-inhibiting activity of the native GPIR and having a prolonged-action in vivo which is obtained by oxidation of its osidic units by the action of periodate ions, and simultaneous reduction with cyanoborohydride ions. Said modified glycoprotein may be coupled to an antibody or a fragment thereof in order to form an immunotoxin having a prolonged-action in vivo.

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European Journal of Biochemistry, vol. 147, No. 1, Feb., 1985, "Modification of the Carbohydrate in Ricin with Metaperiodate-Cyano Borohydrate Mixtures," Thorpe et al.
Chemical Abstracts, vol. 103, No. 13, Nov. 11, 1985, pp. 244-245, No. 155549e, Columbus, Ohio; Skilleter et al., "Modification of the Carbohydrate in Ricin with Metaperiodate and Cyanoborohydrate Mixtures: Effect on Binding, Uptake and Toxicity to Parenchymal etc"
CA:103:208487s "Immunotoxins Containing Ricin A or B Chains with Modified Carbohydrate Residues . . . ".

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