Stereoselective process for making substituted amino acid deriva

Details Stereoselective process for making substituted amino acid deriva Stereoselective process for making substituted amino acid deriva

1997-08-25

1998-07-21

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548532, C07D20716

Patent

active

057837090

ABSTRACT:
The invention encompasses a method for the stereoselective synthesis of alkyl proline and other amino acid derivatives which are intermediates of the farnesyl-protein transferase inhibiting CA.sup.1 A.sup.2 X motif of the protein Ras. The instant process employs an efficient enolates mediated by a chiral auxiliary to provide acyclic and cyclic precursors.

REFERENCES:
patent: 5413999 (1995-05-01), Vacca et al.
patent: 5627202 (1997-05-01), DeSolms
J. Y. L. Chung et al., J. Org. Chem, 55, pp. 270-277 (1990).
D. A. Evans et al., J. Am. Chem. Soc., 109, pp. 1751-7158 (1987).
ABE et al., S. J. High Res. Chromo. Comm., pp. 549, (1981).

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