Diphenylalkanoether and diphenylalkanone oximeether derivatives

Details Diphenylalkanoether and diphenylalkanone oximeether derivatives Diphenylalkanoether and diphenylalkanone oximeether derivatives

1980-04-02

1983-06-14

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424275, 424285, 549 60, 424330, 549 61, 549 65, 549 68, 549 69, 549 75, 549472, 549473, 549474, 549476, 549478, 549479, 549480, 549481, 549487, 549491, 549496, 546261, 546264, 546265, 546283, 546284, 546286, 546294, 546300, 546312, 546334, 260465E, 564220, 564256, 564257, 564346, C07D33304, C07C 8728, C07D30734, A61K 3138, A61K 3134, A61K 31135

Patent

active

043884695

ABSTRACT:
Diphenylalkanoether and diphenylalkanone oxime-ether derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each independently an aryl group optionally substituted with 1 to 3 substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro, cyano, di(C.sub.1 -C.sub.4)alkylamino, amino, benzyloxy, hydroxyl, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 alkanoylamino, C.sub.1 -C.sub.4 alkylamino and N-(C.sub.1 -C.sub.4)alkyl-N-(C.sub.1 -C.sub.4)alkanoylamino, Z.sup.1 is a group of the formula: ##STR2## (wherein R.sup.3 and R.sup.4 are each independently a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or an ar(C.sub.1 -C.sub.4)alkyl group or, when taken together with the adjacent nitrogen atom to which they are attached, represent a nitrogen-containing 5 to 7-membered saturated heterocyclic group optionally having an oxygen atom or an additional nitrogen atom as the hetero atom in addition to the said nitrogen atom and, in case of having the additional nitrogen atom, bearing a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, an ar(C.sub.1 -C.sub.4)alkyl group or a phenyl group thereon), ##STR3## is a group of the formula: ##STR4## or the formula: ##STR5## A.sup.1 is a C.sub.2 -C.sub.6 alkylene group and A.sup.2 is a C.sub.2 -C.sub.4 alkylene group, and non-toxic, pharmaceutically acceptable acid addition salts thereof, which have cerebral vasodilating activity and antihypoxic activity.

REFERENCES:
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patent: 4192818 (1980-03-01), van Dijk et al.
Sperber, Nathan et al., J. Am. Chem. Soc., vol. 71 (1949) pp. 887-890.
Conant, James Bryant, "The Chemistry of Organic Compounds" (1947) MacMillan Co. Publ., at p. 264.
J. Pharmacol. Exptl. Therap., vol. 112, 318-325 (1954).
J. Pharm. Sci., vol. 54 (1965) p. 1373.
Farmaco (Pavia), Ed. Sci., vol. 19 (1964) pp. 688-702.

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