Heparin monitoring system and methodology

Details Heparin monitoring system and methodology Heparin monitoring system and methodology

1988-04-05

1990-03-27

McGraw, Vincent P.

Optics: measuring and testing

Blood analysis

128633, 356407, 356414, G01N 33487, G01N 2131

Patent

active

049115499

ABSTRACT:
A system for measuring heparin concentration in a sample of blood plasma includes a vessel for containing a sample of blood plasma to which a dye such as azure A has been added, and a light source for transmitting light at each of two different wavelengths through the sample while the sample is in the vessel, one of which wavelengths may be relatively insensitive to heparin dilution. A detector arrangement detects the light at each of the two different wavelengths that is transmitted through the sample to produce two different signals, each one of which signals is indicative of the light transmitted through the sample at a respective one of the two different wavelengths. Processing components process the two different signals to produce an output signal indicative of the amount of heparin concentration that compensates for the effect of plasma dilution by comparing the two signals.

REFERENCES:
patent: 3910701 (1975-10-01), Henderson et al.
patent: 4195932 (1980-04-01), Popelka
Grant et al, "Metachromatic Activity of Heparin and Heparin Fragments" Analytical Biochemistry, vol. 137, pp. 25-31, 1983.
Jacques, "Detection of Heparin and Related Sulfated Mucopolysaccharides", Method of Biochemical Analysis, vol. 24, pp. 238-241, 1977.
Jacques et al., "A Modified Method for the Colormetric Determination of Heparin", Canadian Journal of Physiology & Pharacology, vol. 45, pp. 789-794, 1967.
Gundry et al., "Clinical Evaluation of a New Rapid Heparin Assay Using the Dye Azurea", American Journal of Surgery, vol. 148, pp. 191-193, 1984.
Klein, "A Colorimetric Assay for Chemical Heparin in Plasma", Analytical Biochemistry, vol. 1241, pp. 59-64, 1982.
Durove et al, "Instrument for Measuring Microconcentrations of Indicator Dyes in Blood", Biomed. Eng. (U.S.A.), vol. 12, #1, Jan.-Feb. 1978, pp. 20-22.

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