Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-12-23
1998-07-21
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 4351721, 4242481, C12Q 168, C12P 1934, C12N 1500
Patent
active
057833869
ABSTRACT:
Polynucleotides associated with virulence in mycobacteria, and particularly a fragment of DNA isolated from M. bovis that contains a region encoding a putative sigma factor. Also provided are methods for a DNA sequence or sequences associated with virulence determinants in mycobacteria, and particularly in M. tuberculosis and M. bovis. The invention also provides corresponding polynucleotides associated with avirulence in mycobacteria. In addition, the invention provides a method for producing strains with altered virulence or other properties which can themselves be used to identify and manipulate individual genes.
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Bloom Barry R.
Collins Desmond Michael
de Lisle Geoffrey W.
Jacobs, Jr. William R.
Kawakami Riku Pamela
Agresearch, New Zealand Pastoral Agriculture Research Institute
Albert Einstein College of Medicine of Yeshiva University
Housel James C.
Swartz Rodney P.
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