Process for the preparation of immunoglobulin for intravenous ad

Details Process for the preparation of immunoglobulin for intravenous ad Process for the preparation of immunoglobulin for intravenous ad

1980-03-18

1981-03-17

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 85, 424101, 424177, A23J 000

Patent

active

042566312

ABSTRACT:
The specification describes an economical process for the preparation of immunoglobulin for intravenous administration. An immunoglobulin can be, in accordance with the process, purified by a combination of a fractional precipitation method and an affinity chromatography. As a precipitant, divalent or trivalent metal salts are used and a complex of human IgG and a polyhydroxy polymeric compound is employed as an adsorbent. Purified immunoglobulin contains little or no aggregated or partially denatured globulin which is believed to cause anaphylaxis when administered intravenously. Prior art techniques cannot economically provide immunoglobulin in such a purified form and only intramuscular injections were feasible. Intravenous administrations allow immunoglobulin to be dosed in a larger amount and to act much faster than intramuscular injections.

REFERENCES:
patent: 2770616 (1956-11-01), Cohn
patent: 3641235 (1972-02-01), Weiss
patent: 4046722 (1977-09-01), Rowland

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