Process for the alkylation of alkyl-or benzylcyanogen derivative

Details Process for the alkylation of alkyl-or benzylcyanogen derivative Process for the alkylation of alkyl-or benzylcyanogen derivative

1998-12-16

2000-11-07

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546246, 558328, C07D21134, C07C25503

Patent

active

061438960

ABSTRACT:
A process for the alkylation of compounds of the formula II ##STR1## where the reaction with the alkylating agent is carried out in the presence of a base and a trialkylamine and/or trialkylphosphine.

REFERENCES:
patent: 3668255 (1972-06-01), Meuly et al.
patent: 4254129 (1981-03-01), Carr et al.
patent: 5739375 (1998-04-01), Fischer
Smith et al., "Relative Nucleophilicites of Carbanions Derived From .alpha.-Substituted Phenylacetonitriles", J. Org. Chem., 36(15):2132-2137 (1971).
Trivedi et al., "Inhibitors of Acyl-CoA:Cholesterol Acyltransferase. 4. A Novel Series of Urea ACAT Inhibitiors as Potential Hypocholesterolemic Agents", J. Med. Chem., 36:3300-3307 (1993).
English Derwent Abstract of DE 22 06 778. Aug. 16, 1973.

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