Semi-synthesis of human insulin

Details Semi-synthesis of human insulin Semi-synthesis of human insulin

1980-04-09

1982-03-16

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435886, 435896, 424178, C12P 2106

Patent

active

043201962

ABSTRACT:
A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.

REFERENCES:
patent: 3276961 (1966-10-01), Bodanszky et al.
patent: 3903068 (1975-02-01), Ruttenberg
Yoshida et al., FEBS Letters, 15(2), 129-132 (1971).
Schmitt et al., Hoppe-Seyler's Z. Physiol. Chem., 359, 799-802 (1978).
Obermeier et al. Hoppe-Seyler's Physiol. Chem., 357, 759-767 (1976).
Inouye et al., JACS, 101, 751-752 (1979).
Morihara et al., Nature, 280, 412-413 (1979).
Morihara et al., Arch. Biochem. Biophys., 126, 971-973 (1968).

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