Method for the production of cephalosporins

Details Method for the production of cephalosporins Method for the production of cephalosporins

1973-12-04

1976-03-23

Tanenholtz, Alvin E.

Textiles: fiber preparation

195 30, C12D 900

Patent

active

039458881

ABSTRACT:
A new method for production of a cephalosporin ester (I) which comprises reacting a derivative of an organic acid (II) with a 7-aminocephem compound (III) in the presence of an enzyme of a microorganism of one of the genera Escherichia, Bacillus, Proteus and Pseudomonas: ##SPC1## ##EQU1## ##SPC2## wherein R is an unsaturated six-membered carbocyclic ring or five-membered heterocyclic ring residue which may optionally have uncharged substituent groups; R.sup.1 is hydrogen or an uncharged substituent group such as hydroxyl or halogen; R.sup.2 is a hydrogen atom or an organic group which is bound through an oxygen, sulfur or nitrogen atom; COOR.sup.3 is a group which may easily be converted to COOH.

REFERENCES:
patent: 3816253 (1974-06-01), Takahashi et al.
patent: 3862004 (1975-01-01), Takahashi et al.

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