Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain recept

Details Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain recept Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain recept

1998-08-25

2000-11-07

Seaman, D. Margaret

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546123, A61K 3144, C07D47102

Patent

active

061437603

ABSTRACT:
The present invention encompasses structures of the Formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: x is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and

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G. White et al., (1995). Harwood Academic Publishers GmbH., Receptors and Channels, "Human .alpha. and .beta. Subunits Contribute to the EC50 GABA at the GABAa Receptor Expressed in Xenopus Oocytes". vol. 3, pp. 1-5.
Geoffrey White and David Gorley, (1995). Molecular Neuroscience, NeuroReport., "Benzodiazepine site inverse agonists can selectively inhibit subtypes of the GABA a receptor." vol. 6, pp. 1313-1316.
Kondo Kazumi, Patent Abstracts of Japan, vol. 13. No. 260. Jun. 15, 1999.
J. Heindl et al., (1977), Eur. J. Med. Chem, vol. 6. pp. 549-555.

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