Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1997-06-19
2000-11-07
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
4352523, 43525233, 435325, 4353201, 435419, 43525411, 4352543, 536 232, 536 2431, C12N 920, C12N 1509, C12N 1570, C12N 1555
Patent
active
061435449
ABSTRACT:
The invention provides a new human lysophospholipase (JHLP) and polynucleotides which identify and encode IHLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating inflammation and disorders associated with expression of IHLP.
REFERENCES:
Selle, H., et al., "Glycerophosphocholine release in human erythrocytes," Eur. J. Biochem, 212:411-416 (1993).
Endresen, M., et al., "Increased lipolytic activity of sera from pre-eclamptic women due to the presence of a lysophospholipase," Scand. J. Clin Lab Invest, 53:733-739 (1993).
Anderson, R., et al., ".alpha.-Tocopherol Prevents Cyclosporin A-Mediated Activation of Phospholipase A.sup.2 and Inhibition of Na+, K.sub.- -;Adenosine Triphosphatase Activity in Cultured Hamster Renal Tubular Cells," Toxicology and Applied Pharmacology, 125:176-183 (1994).
Hong, K., et al. (GI 244500 and GI 244501) GenBank Sequence Database (Accession S79600), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Sugimoto, H., et al., "Purification, Characterization, and Inhibition by Phosphatidic Acid of Lysophospholipase Transacylase from Rat Liver," The Journal of Biological Chemistry, 269(8) :6252-6258 (1994).
Sugimoto et al. "Purification, cDNA cloning, and regulation of lysophospholipase from rat liver" J. Biol. Chem. 271 (13), 7705-7711 (Mar. 29, 1996).
Corley Neil C.
Hillman Jennifer L.
Murry Lynn E.
Shah Purvi
Billings Lucy J.
Hendricks Keith D.
Incyte Pharmaceuticals Inc.
Mayhew Bradley S.
Price Leanne C.
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